SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells.

@article{Weisbrod2013SK4CA,
  title={SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells.},
  author={David Weisbrod and Asher Peretz and Anna Ziskind and Nataly Menaker and Shimrit Oz and Lili Barad and Sivan Eliyahu and Joseph Itskovitz-Eldor and Nathan Dascal and Daniel Khananshvili and Ofer Binah and Bernard Attali},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 18},
  pages={E1685-94}
}
Proper expression and function of the cardiac pacemaker is a critical feature of heart physiology. Two main mechanisms have been proposed: (i) the "voltage-clock," where the hyperpolarization-activated funny current If causes diastolic depolarization that triggers action potential cycling; and (ii) the "Ca(2+) clock," where cyclical release of Ca(2+) from Ca(2+) stores depolarizes the membrane during diastole via activation of the Na(+)-Ca(2+) exchanger. Nonetheless, these mechanisms remain… CONTINUE READING
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