SK channels and ventricular arrhythmias in heart failure.

@article{Chang2015SKCA,
  title={SK channels and ventricular arrhythmias in heart failure.},
  author={Po-Cheng Chang and Peng-Sheng Chen},
  journal={Trends in cardiovascular medicine},
  year={2015},
  volume={25 6},
  pages={
          508-14
        }
}
Small-conductance Ca(2+)-activated K(+) (SK) currents are important in the repolarization of normal atrial (but not ventricular) cardiomyocytes. However, recent studies showed that the SK currents are upregulated in failing ventricular cardiomyocytes, along with increased SK channel protein expression and enhanced sensitivity to intracellular Ca(2+). The SK channel activation may be either anti-arrhythmic or pro-arrhythmic, depending on the underlying clinical situations. While the SK channel… CONTINUE READING
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