SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance

@article{Nazzaro2012SKCM,
  title={SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance},
  author={Cristiano Nazzaro and Barbara Greco and Milica Cerovic and Paul Baxter and T Rubino and Massimo Trusel and Daniela Parolaro and Tatiana Tkatch and Fabio Benfenati and Paola Pedarzani and Raffaella Tonini},
  journal={Nature Neuroscience},
  year={2012},
  volume={15},
  pages={284-293}
}
Endocannabinoids (eCBs) regulate neuronal activity in the dorso-lateral striatum (DLS), a brain region that is involved in habitual behaviors. How synaptic eCB signaling contributes to habitual behaviors under physiological and pathological conditions remains unclear. Using a mouse model of cannabinoid tolerance, we found that persistent activation of the eCB pathway impaired eCB-mediated long-term depression (LTD) and synaptic depotentiation in the DLS. The loss of eCB LTD, occurring… CONTINUE READING
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