SK&F 89124, A POTENT AND SELECTIVE AGONIST AT PREJUNCTIONAL DOPAMINE RECEPTORS

@article{Hieble1989SKF8A,
  title={SK\&F 89124, A POTENT AND SELECTIVE AGONIST AT PREJUNCTIONAL DOPAMINE RECEPTORS},
  author={Jacob Paul Hieble and Anthony C. Sulpizio and Henry M. Sarau and Kathryn E. Flaim and Alan Blumberg and James P. Mccafferty and Robert L. Zeid},
  journal={Fundamental \& Clinical Pharmacology},
  year={1989},
  volume={3}
}
Summary— SK&F 89124 (4‐[2‐(N,N‐di‐n‐propylamino)ethyl]‐7‐hydroxy‐2(3H) indolone) can be considered as a derivative of N,N‐di‐n‐propyldopamine (DPDA) in which the meta‐hydroxyl is replaced by a cyclic amide function. SK&F 89124 is at least one order of magnitude more potent than DPDA as an agonist at peripheral inhibitory prejunctional dopamine receptors (DA2 receptors) in the isolated perfused rabbit ear artery. A potent agonist action of SK&F 89124 at the DA2 receptor can also be demonstrated… 

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