SJ-3366, a Unique and Highly Potent Nonnucleoside Reverse Transcriptase Inhibitor of Human Immunodeficiency Virus Type 1 (HIV-1) That Also Inhibits HIV-2

@article{Buckheit2001SJ3366AU,
  title={SJ-3366, a Unique and Highly Potent Nonnucleoside Reverse Transcriptase Inhibitor of Human Immunodeficiency Virus Type 1 (HIV-1) That Also Inhibits HIV-2},
  author={R. Buckheit and K. Watson and V. Fliakas-Boltz and Julie Russell and T. L. Loftus and M. C. Osterling and J. Turpin and L. Pallansch and E. White and J. Lee and S.-H. Lee and J.-W. Oh and H.-S. Kwon and S.-G. Chung and E.-H. Cho},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2001},
  volume={45},
  pages={393 - 400}
}
  • R. Buckheit, K. Watson, +12 authors E.-H. Cho
  • Published 2001
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
ABSTRACT We have identified and characterized a potent new nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1) that also is active against HIV-2 and which interferes with virus replication by two distinct mechanisms. 1-(3-Cyclopenten-1-yl)methyl-6-(3,5-dimethylbenzoyl)-5-ethyl-2,4-pyrimidinedione (SJ-3366) inhibits HIV-1 replication at concentrations of approximately 1 nM, with a therapeutic index of greater than 4 × 106. The efficacy and… Expand
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