SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.

@article{Wang2012SIX1IL,
  title={SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.},
  author={Chu-An Wang and Paul Jedlicka and Aaron N Patrick and Douglas S. Micalizzi and Kimberly C. Lemmer and Erin Deitsch and Matias Cas{\'a}s-Selves and J Chuck Harrell and Heide L. Ford},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 5},
  pages={1895-906}
}
An association between lymph node metastasis and poor prognosis in breast cancer was observed decades ago. However, the mechanisms by which tumor cells infiltrate the lymphatic system are not completely understood. Recently, it has been proposed that the lymphatic system has an active role in metastatic dissemination and that tumor-secreted growth factors… CONTINUE READING