SIVmac₂₃₉-Nef down-regulates cell surface expression of CXCR4 in tumor cells and inhibits proliferation, migration and angiogenesis.

@article{Cai2012SIVmacNefDC,
  title={SIVmac₂₃₉-Nef down-regulates cell surface expression of CXCR4 in tumor cells and inhibits proliferation, migration and angiogenesis.},
  author={Chengzhong Cai and Fiona R. Rodepeter and Annette Rossmann and Afshin Teymoortash and Jin-Seok Lee and K. R. Quint and Pietro Di Fazio and Matthias Ocker and Jochen Werner and Robert Mandic},
  journal={Anticancer research},
  year={2012},
  volume={32 7},
  pages={2759-68}
}
AIM To evaluate if the lentiviral accessory protein Nef can down-regulate the C-X-C chemokine receptor type 4 (CXCR4) in tumor cells and affect tumor cell proliferation, migration and angiogenesis. MATERIALS AND METHODS HeLa-(ACC) cells, which according to genotype analysis are virtually identical to the cervical cancer-derived HeLa cell line, were… CONTINUE READING