SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors

@article{Berger2009SIVMACVI,
  title={SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors},
  author={Gregory L. Berger and Caroline Goujon and J-L Darlix and Andrea Cimarelli},
  journal={Gene Therapy},
  year={2009},
  volume={16},
  pages={159-163}
}
Lentiviral vector (LV)-mediated gene therapy bears an intrinsic risk of insertional mutagenesis following integration into the host genome. Nonintegrative LVs may offer an alternative avenue at least in nondividing cells where episomal viral DNA persists stably. Owing to their central role in immune system functions, differentiated dendritic cells (DCs) offer an interesting cell target for these vectors. We have previously described that the transduction of DCs with wild-type HIV-1-derived… CONTINUE READING