SIV Latency in Macrophages in the CNS.

  title={SIV Latency in Macrophages in the CNS.},
  author={Lucio Gama and Celina Monteiro Abreu and Erin N. Shirk and Suzanne e. Queen and Sarah E. Beck and Kelly A. Metcalf Pate and Brandon T. Bullock and M. Christine Zink and Joseph L Mankowski and Janice E. Clements},
  journal={Current topics in microbiology and immunology},
Lentiviruses infect myeloid cells, leading to acute infection followed by persistent/latent infections not cleared by the host immune system. HIV and SIV are lentiviruses that infect CD4+ lymphocytes in addition to myeloid cells in blood and tissues. HIV infection of myeloid cells in brain, lung, and heart causes tissue-specific diseases that are mostly observed during severe immunosuppression, when the number of circulating CD4+ T cells declines to exceeding low levels. Antiretroviral therapy… CONTINUE READING


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