SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques.

@article{Boyer2005SIVDV,
  title={SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques.},
  author={Jean D. Boyer and Tara M. Robinson and Michele A. Kutzler and Rose M. Parkinson and Sandra Amelia Calarota and Maninder K. Sidhu and Karuppiah Muthumani and Mark G. Lewis and George N Pavlakis and Barbara K Felber and David Weiner},
  journal={Journal of medical primatology},
  year={2005},
  volume={34 5-6},
  pages={262-70}
}
Current evidence suggests that a strong induced CD8 human immunodeficiency virus type 1 (HIV-1)-specific cell mediated immune response may be an important aspect of an HIV vaccine. The response rates and the magnitude of the CTL responses induced by current DNA vaccines in humans need to be improved and cellular immune responses to DNA vaccines can be enhanced in mice by co-delivering DNA plasmids expressing immune modulators. Two reported to work well in the mouse systems are interleukin (IL… CONTINUE READING