SIRTUIN 1: regulating the regulator.

  title={SIRTUIN 1: regulating the regulator.},
  author={Barbara Zschoernig and Ulrich Mahlknecht},
  journal={Biochemical and biophysical research communications},
  volume={376 2},
Earlier analyses on the sirtuin family of histone deacetylases and its well-known member SIRT1 had their primary focus mostly on the identification of cellular targets exploring molecular mechanisms and functional networks in the control of metabolic homeostasis, differentiation, apoptosis and cell survival. However, only little is known about the regulation of SIRT1 itself, so far. Presently, SIRT1 is gaining increasing importance in the development of innovative treatment strategies for… CONTINUE READING