SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

@inproceedings{Vazquez2016SIRT7P,
  title={
SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair},
  author={Berta N. Vazquez and Joshua K. Thackray and Nicolas G Simonet and Noriko Kane-Goldsmith and Paloma Mart{\'i}nez-Redondo and Trang T. Nguyen and Samuel F Bunting and Alejandro Vaquero and Jay A. Tischfield and Lourdes Serrano},
  booktitle={The EMBO journal},
  year={2016}
}
Sirtuins, a family of protein deacetylases, promote cellular homeostasis by mediating communication between cells and environment. The enzymatic activity of the mammalian sirtuin SIRT7 targets acetylated lysine in the N-terminal tail of histone H3 (H3K18Ac), thus modulating chromatin structure and transcriptional competency. SIRT7 deletion is associated with reduced lifespan in mice through unknown mechanisms. Here, we show that SirT7-knockout mice suffer from partial embryonic lethality and a… CONTINUE READING
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A SIRT7dependent acetylation switch of GABPbeta1 controls mitochondrial function

  • D Ryu, YS Jo, +9 authors J Auwerx
  • Cell Metab 20:
  • 2014
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