SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.

@article{Yoshizawa2014SIRT7CH,
  title={SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.},
  author={Tatsuya Yoshizawa and Md Fazlul Karim and Yoshifumi Sato and Takafumi Senokuchi and Keishi Miyata and Takaichi Fukuda and Chisa Go and Masayoshi Tasaki and Kohei Uchimura and Tsuyoshi Kadomatsu and Zhe Tian and Christian Smolka and Tomohiro Sawa and Motohiro Takeya and Kazuhito Tomizawa and Yukio Ando and Eiichi Araki and Takaaki Akaike and Thomas Braun and Yuichi Oike and Eva Bober and Kazuya Yamagata},
  journal={Cell metabolism},
  year={2014},
  volume={19 4},
  pages={712-21}
}
Sirtuins (SIRT1-7) have attracted considerable attention as regulators of metabolism over the past decade. However, the physiological functions and molecular mechanisms of SIRT7 are poorly understood. Here we demonstrate that Sirt7 knockout mice were resistant to high-fat diet-induced fatty liver, obesity, and glucose intolerance, and that hepatic… CONTINUE READING
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