SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition.

@article{He2017SIRT6RM,
  title={SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition.},
  author={Jiangping He and Guangya Zhang and Qi Pang and Cong Yu and Jie Xiong and Jing Zhu and Fengling Chen},
  journal={The FEBS journal},
  year={2017},
  volume={284 9},
  pages={1324-1337}
}
SIRT6 is a pivotal regulator of lipid metabolism. It is also closely connected to cardiovascular diseases, which are the main cause of death in diabetic patients. We observed a decrease in the expression of SIRT6 and key autophagy effectors (ATG5, LC3B, and LAMP1) in ox-LDL-induced foam cells, a special form of lipid-laden macrophages. In these cells, SIRT6 WT but not SIRT6 H133Y overexpression markedly reduced foam cell formation, as shown by Oil Red O staining, while inducing autophagy flux… CONTINUE READING

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