SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.

@article{Khongkow2013SIRT6MP,
  title={SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.},
  author={Mattaka Khongkow and Yolanda Olmos and Chun Wei Gong and Ana Rita Gomes and Lara J Monteiro and Ernesto Yag{\"u}e and Tania B. Cavaco and Pasarat Khongkow and Ellen Pui Sum Man and Sasiwan Laohasinnarong and Chang Uk Koo and Narumi Harada-Shoji and Janice W-H Tsang and R C Coombes and Bjoern Schwer and U Y Khoo and Eric Wing-Fai Lam},
  journal={Carcinogenesis},
  year={2013},
  volume={34 7},
  pages={
          1476-86
        }
}
In this study, we report the identification of a novel role of SIRT6 in both epirubicin and paclitaxel resistance in breast cancer. We found that SIRT6 protein levels are elevated in paclitaxel- and epirubicin-resistant MCF-7 cells compared with the parental sensitive cells. SIRT6 knockout and depletion sensitized cells to both paclitaxel and epirubicin treatment, whereas SIRT6 ectopic overexpression led to increased resistance to paclitaxel and epirubicin. Moreover, our data suggest that SIRT6… CONTINUE READING
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