SIRT6 histone deacetylase functions as a potential oncogene in human melanoma

@inproceedings{GarciaPeterson2017SIRT6HD,
  title={SIRT6 histone deacetylase functions as a potential oncogene in human melanoma},
  author={Liz Mariely Garcia-Peterson and Mary Ann Ndiaye and Chandra Kant Singh and Gagan Chhabra and Wei Huang and Nihal Ahmad},
  booktitle={Genes & cancer},
  year={2017}
}
Melanoma is an aggressive skin cancer that can rapidly metastasize to become fatal, if not diagnosed early. Despite recent therapeutic advances, management of melanoma remains difficult. Therefore, novel molecular targets and strategies are required to manage this neoplasm. This study was undertaken to determine the role of the sirtuin SIRT6 in melanoma. Employing a panel of human melanoma cells and normal human melanocytes, we found significant SIRT6 mRNA and protein upregulation in melanoma… CONTINUE READING