SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

  title={SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.},
  author={Jeongsoon Park and Yue Chen and Daniel X. Tishkoff and Chao Peng and Minjia Tan and Lunzhai Dai and Zhongyu Xie and Yi Zhang and Bernadette M. M. Zwaans and Mary E. Skinner and David Lombard and Yingming Zhao},
  journal={Molecular cell},
  volume={50 6},
Protein function is regulated by diverse posttranslational modifications. The mitochondrial sirtuin SIRT5 removes malonyl and succinyl moieties from target lysines. The spectrum of protein substrates subject to these modifications is unknown. We report systematic profiling of the mammalian succinylome, identifying 2,565 succinylation sites on 779 proteins. Most of these do not overlap with acetylation sites, suggesting differential regulation of succinylation and acetylation. Our analysis… CONTINUE READING
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