SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells.

@article{Shi2010SIRT3RL,
  title={SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells.},
  author={Tong Shi and Guo Quan Fan and Shu Dong Xiao},
  journal={Journal of digestive diseases},
  year={2010},
  volume={11 1},
  pages={55-62}
}
OBJECTIVE Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD)(+)-dependent protein deacetylase localized on mitochondria and regulates the adaptive thermogenesis in brown adipocytes. This study aims to investigate the role of SIRT3 in hepatic lipid accumulation, and whether the activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) is required. METHODS A retroviral system was used for overexpressing of SIRT3 in HepG2 cells, whereas a lentivirus-mediated vector… CONTINUE READING
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