SIRT3 mediates multi-tissue coupling for metabolic fuel switching.

  title={SIRT3 mediates multi-tissue coupling for metabolic fuel switching.},
  author={Kristin E. Dittenhafer-Reed and Alicia L. Richards and Jing Fan and Michael Smallegan and Alireza Fotuhi Siahpirani and Zachary A. Kemmerer and Tomas A. Prolla and Sushmita Roy and Joshua J. Coon and John M Denu},
  journal={Cell metabolism},
  volume={21 4},
SIRT3 is a member of the Sirtuin family of NAD(+)-dependent deacylases and plays a critical role in metabolic regulation. Organism-wide SIRT3 loss manifests in metabolic alterations; however, the coordinating role of SIRT3 among metabolically distinct tissues is unknown. Using multi-tissue quantitative proteomics comparing fasted wild-type mice to mice lacking SIRT3, innovative bioinformatic analysis, and biochemical validation, we provide a comprehensive view of mitochondrial acetylation and… CONTINUE READING
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