SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology.

@article{Harting2010SIRT2mediatedPD,
  title={SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology.},
  author={Kai Harting and Bernd Kn{\"o}ll},
  journal={European journal of cell biology},
  year={2010},
  volume={89 2-3},
  pages={262-9}
}
Protein function is considerably altered by posttranslational modification. In recent years, cycles of acetylation/deacetylation emerged as fundamental regulators adjusting biological activity of many proteins. Particularly, protein deacetylation by Sirtuins, a family of atypical histone deacetylases (HDACs), was demonstrated to regulate fundamental cell biological processes including gene expression, genome stability, mitosis, nutrient metabolism, aging, mitochondrial function and cell… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 108 references

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2007
View 8 Excerpts
Highly Influenced

Sirtuins in mammals: insights into their biological function.

The Biochemical journal • 2007
View 17 Excerpts
Highly Influenced

Metabolite of SIR2 reaction modulates TRPM2 ion channel.

The Journal of biological chemistry • 2006
View 4 Excerpts
Highly Influenced

Actin-binding proteins take the reins in growth cones

Nature Reviews Neuroscience • 2008
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…