SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.

@article{North2014SIRT2IT,
  title={SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.},
  author={Brian J North and Michael A Rosenberg and Karthik B. Jeganathan and Angela V. Hafner and Shaday Mich{\'a}n and Jing Dai and Darren J. Baker and Yana Cen and Lindsay E Wu and Anthony A. Sauve and Jan M van Deursen and Anthony Rosenzweig and David A Sinclair},
  journal={The EMBO journal},
  year={2014},
  volume={33 13},
  pages={1438-53}
}
Mice overexpressing the mitotic checkpoint kinase gene BubR1 live longer, whereas mice hypomorphic for BubR1 (BubR1(H/H)) live shorter and show signs of accelerated aging. As wild-type mice age, BubR1 levels decline in many tissues, a process that is proposed to underlie normal aging and age-related diseases. Understanding why BubR1 declines with age and how to slow this process is therefore of considerable interest. The sirtuins (SIRT1-7) are a family of NAD(+)-dependent deacetylases that can… CONTINUE READING
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