SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress

@article{Inoue2007SIRT2AT,
  title={SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress},
  author={Takeshi Inoue and Masaharu Hiratsuka and Mitsuhiko Osaki and Hideto Yamada and Ichiro Kishimoto and Sachiko Yamaguchi and Seiji Nakano and Masuko Katoh and Hiromichi Ito and Mitsuo Oshimura},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={945-957}
}
We previously identified SIRT2, an nicotinamide adenine dinucleotide (NAD)-dependent tubulin deacetylase, as a protein downregulated in gliomas and glioma cell lines, which are characterized by aneuploidy. Other studies reported SIRT2 to be involved in mitotic progression in the normal cell cycle. We herein investigated whether SIRT2 functions in the… CONTINUE READING
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