SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.

@article{Holloway2010SIRT1RD,
  title={SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.},
  author={Kimberly R. Holloway and Tara N. Calhoun and Madhurima Saxena and Cheynita F Metoyer and Ethan F Kandler and Chantal A. Rivera and Kevin Pruitt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 20},
  pages={9216-21}
}
Sirtuin 1 (SIRT1) is a class III histone deacetylase that deacetylates histone and nonhistone proteins to regulate gene transcription and protein function. Because SIRT1 regulates very diverse responses such as apoptosis, insulin sensitivity, autophagy, differentiation, and stem cell pluripotency, it has been a challenge to reconcile how it orchestrates such pleiotropic effects. Here we show that SIRT1 serves as an important regulator of Wnt signaling. We demonstrate that SIRT1 loss of function… CONTINUE READING