SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.

@article{Price2012SIRT1IR,
  title={SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.},
  author={Nathan L. Price and Ana Patr{\'i}cia Gomes and Alvin J Y Ling and Filipe Valente Duarte and Alejandro Mart{\'i}n-Montalvo and Brian J North and Beamon Agarwal and Lan Ye and Giorgio Ramadori and Jo{\~a}o Soeiro Teodoro and Basil P. Hubbard and Ana Teresa Varela and James G. Davis and Behzad Varamini and Angela Hafner and Ruin Moaddel and Anabela Pinto Rolo and Roberto Coppari and Carlos Manuel Marques Palmeira and Rafael de Cabo and Joseph A. Baur and David A Sinclair},
  journal={Cell metabolism},
  year={2012},
  volume={15 5},
  pages={675-90}
}
Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but whether SIRT1 mediates these benefits is the subject of debate. To circumvent the developmental defects of germline SIRT1 knockouts, we have developed an inducible system that permits whole-body deletion of SIRT1 in adult mice. Mice treated with a moderate dose of resveratrol showed increased mitochondrial biogenesis and function, AMPK activation, and increased NAD(+) levels in skeletal muscle, whereas… CONTINUE READING
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