SIRT1 is downregulated during peripheral blood stem cell mobilization in healthy donors by granulocyte-colony stimulating factor

@article{Sugiyama2016SIRT1ID,
  title={SIRT1 is downregulated during peripheral blood stem cell mobilization in healthy donors by granulocyte-colony stimulating factor},
  author={Akinori Sugiyama and T Yujiri and Mayumi Tanaka and Yoshinori Tanaka and Yukinori Nakamura and Yukio Tanizawa},
  journal={Annals of Hematology},
  year={2016},
  volume={95},
  pages={1381-1382}
}
Dear Editor, Nicotinamide phosphoribosyltransferase (NAMPT) mediates granulocyte-colony stimulating factor (G-CSF)-triggered granulopoiesis in healthy individuals [1] and is a rate-limiting enzyme in conversion of nicotinamide into nicotinamide adenine dinucleotide, NAD, which is crucial for SIRT1 activation. SIRT1 mediates the lifespan extension effects of caloric restriction and deacetylates histones and several nonhistone substrates involved in multiple signaling pathways [2], and SIRT1… CONTINUE READING

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