SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.

@article{McBurney2013SIRT1IA,
  title={SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.},
  author={Michael W McBurney and Katherine V. Clark-Knowles and Annabelle Z Caron and Douglas A. Gray},
  journal={Genes & cancer},
  year={2013},
  volume={4 3-4},
  pages={125-34}
}
SIRT1 is a NAD(+)-dependent protein deacetylase that has a very large number of established protein substrates and an equally impressive list of biological functions thought to be regulated by its activity. Perhaps as notable is the remarkable number of points of conflict concerning the role of SIRT1 in biological processes. For example, evidence exists suggesting that SIRT1 is a tumor suppressor, is an oncogene, or has no effect on oncogenesis. Similarly, SIRT1 is variably reported to induce… CONTINUE READING
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