SIRT1 inhibitory diterpenoids from the Vietnamese medicinal plant Croton tonkinensis.


Silent information regulator two ortholog 1 (SIRT1) is a member of the sirtuin deacetylase family of enzymes that removes acetyl groups from the lysine residues in histones and other proteins. It has been suggested that SIRT1 inhibitors might be beneficial in the treatment of cancer and neurodegenerative diseases. Bioassay-guided fractionation of the MeOH… (More)
DOI: 10.1055/s-0029-1240863


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