SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.

@article{Kuningas2007SIRT1GA,
  title={SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.},
  author={Maris Kuningas and Mari{\"e}lle Putters and Rudi G J Westendorp and Pieternella E Slagboom and Diana van Heemst},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2007},
  volume={62 9},
  pages={960-5}
}
The (Silent Information Regulator 2) Sir2 gene has been shown to regulate the life span of several model organisms. In mammals, the evolutionarily conserved homologue (Sirtuin 1) SIRT1 regulates neuroprotection, metabolism, and cell survival in response to stress. Based on these data, we hypothesized that SIRT1 might influence the prevalence of age-related diseases and modify the life span of humans. In order to test this, we genotyped five single nucleotide polymorphisms (SNPs) in 1245… CONTINUE READING
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