SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis

@inproceedings{Li2016SIRT1FH,
  title={SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis},
  author={Yu-ming Li and Shangcheng Xu and Jing Li and Lu Zheng and Min Feng and Xiaoya Wang and Keqiang Han and Huifeng Pi and Min Li and Xiaobing Huang and Nan You and Yewang Tian and Guohua Zuo and Hongyan Li and Hongzhi Zhao and Ping Deng and Zheng-ping Yu and Zhou Zhou and Ping Liang},
  booktitle={Oncotarget},
  year={2016}
}
SIRT1 is a multifaceted NAD+-dependent protein deacetylase known to act as a tumor promoter or suppressor in different cancers. Here, we describe a novel mechanism of SIRT1-induced hepatocellular carcinoma (HCC) metastasis. SIRT1 overexpression was frequently detected in human HCC specimens and was associated with microvascular invasion (P = 0.0039… CONTINUE READING