SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.

@article{Ramadori2011SIRT1DI,
  title={SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.},
  author={Giorgio Ramadori and Teppei Fujikawa and Jason B Anderson and Eric D. Berglund and Renata Fraz{\~a}o and Shaday Mich{\'a}n and Claudia R. Vianna and David A Sinclair and Carol F Elias and Roberto Coppari},
  journal={Cell metabolism},
  year={2011},
  volume={14 3},
  pages={
          301-12
        }
}
Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions. Thus, understanding the pathways protecting against diet-induced metabolic imbalance is of paramount medical importance. Here, we show that mice lacking SIRT1 in steroidogenic factor 1 (SF1) neurons are hypersensitive to dietary obesity owing to maladaptive energy expenditure. Also, mutant mice have increased susceptibility to developing dietary T2DM due to… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 66 CITATIONS, ESTIMATED 64% COVERAGE

SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression.

  • American journal of physiology. Endocrinology and metabolism
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2012
2019

CITATION STATISTICS

  • 9 Highly Influenced Citations

  • Averaged 6 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

SmallmoleculeactivatorsofSIRT1 as therapeutics for the treatment of type 2 diabetes

J. C. Milne, P. D. Lambert, +8 authors C.B
  • Nature 450,
  • 2007
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Resveratrol improveshealthandsurvivalofmiceonahighcaloriediet

J. A. Baur, K. J. Pearson, +7 authors K. Lewis
  • Nature
  • 2006
VIEW 14 EXCERPTS
HIGHLY INFLUENTIAL