SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice

@inproceedings{Mercken2014SIRT1BN,
  title={SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice},
  author={Evi M. Mercken and Jia Qi Hu and Susan M. Krzysik-Walker and Min Wei and Ying Li and Michael W McBurney and Rafael de Cabo and Valter D Longo},
  booktitle={Aging cell},
  year={2014}
}
The SIRT1 deacetylase is one of the best-studied putative mediators of some of the anti-aging effects of calorie restriction (CR), but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespan than wild-type mice on an ad libitum diet. Here, we report that median lifespan extension in CR heterozygote SIRT1(+/-) mice was identical (51%) to that observed in wild-type mice, but SIRT1… CONTINUE READING
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