SIRT1 and SIRT2: emerging targets in neurodegeneration

@inproceedings{Donmez2013SIRT1AS,
  title={SIRT1 and SIRT2: emerging targets in neurodegeneration},
  author={Gizem Donmez and Tiago F Outeiro},
  booktitle={EMBO molecular medicine},
  year={2013}
}
Sirtuins are NAD-dependent protein deacetylases known to have protective effects against age-related diseases such as cancer, diabetes, cardiovascular and neurodegenerative diseases. In mammals, there are seven sirtuins (SIRT1-7), which display diversity in subcellular localization and function. While SIRT1 has been extensively investigated due to its initial connection with lifespan extension and involvement in calorie restriction, important biological and therapeutic roles of other sirtuins… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 90 references

Similar Papers

Loading similar papers…