SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch.

@article{Huang2015SIRT1AF,
  title={SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch.},
  author={Kai Huang and Zhi-Qiang Yan and Dan Zhao and Si-Guo Chen and Li-Zhi Gao and Ping Zhang and Bao-rong Shen and Hai-Chao Han and Ying-Xin Qi and Zong-lai Jiang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2015},
  volume={37 5},
  pages={1817-29}
}
BACKGROUND/AIMS Physiological mechanical stretch in vivo helps to maintain the quiescent contractile differentiation of vascular smooth muscle cells (VSMCs), but the underlying mechanisms are still unclear. Here, we investigated the effects of SIRT1 in VSMC differentiation in response to mechanical cyclic stretch. METHODS AND RESULTS Rat VSMCs were subjected to 10%-1.25Hz-cyclic stretch in vitro using a FX-4000T system. The data indicated that the expression of contractile markers, including… CONTINUE READING

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