SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53.

  title={SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53.},
  author={Duk Hoon Kim and Yu Jin Jung and Jung Eun Lee and Ae Sin Lee and Kyung Pyo Kang and Sik Lee and Sung Kwang Park and Myung-Kwan Han and Sang Yong Lee and K. M. Ramkumar and Mi Jeong Sung and Won Kim},
  journal={American journal of physiology. Renal physiology},
  volume={301 2},
  • D. KimY. Jung Won Kim
  • Published 1 August 2011
  • Biology, Chemistry
  • American journal of physiology. Renal physiology
Nephrotoxicity is one of the important dose-limiting factors during cisplatin treatment. There is a growing body of evidence that activation of p53 has a critical role in cisplatin-induced renal apoptotic injury. The nicotinamide adenine dinucleotide-dependent protein deacetylase SIRT1 decreases apoptosis through deacetylating of p53, and resveratrol is known as an activator of SIRT1. To study the role of SIRT1 in cisplatin-induced renal injury through interaction with p53, mouse proximal… 

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