SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

@article{Asher2008SIRT1RC,
  title={SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation},
  author={Gad Asher and David Gatfield and Markus Stratmann and Hans Reinke and Charna Dibner and Florian Kreppel and Raul Mostoslavsky and Frederick W. Alt and Ueli Schibler},
  journal={Cell},
  year={2008},
  volume={134},
  pages={317-328}
}
The mammalian circadian timing system is composed of a central pacemaker in the suprachiasmatic nucleus of the brain that synchronizes countless subsidiary oscillators in peripheral tissues. The rhythm-generating mechanism is thought to rely on a feedback loop involving positively and negatively acting transcription factors. BMAL1 and CLOCK activate the expression of Period (Per) and Cryptochrome (Cry) genes, and once PER and CRY proteins accumulate to a critical level they form complexes with… Expand
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