SIRT1 Histone Deacetylase Expression Is Associated with Microsatellite Instability and CpG Island Methylator Phenotype in Colorectal Cancer

@inproceedings{Nosho2009SIRT1HD,
  title={SIRT1 Histone Deacetylase Expression Is Associated with Microsatellite Instability and CpG Island Methylator Phenotype in Colorectal Cancer},
  author={Katsuhiko Nosho and Kaori Shima and Natsumi Irahara and Shoko Kure and Ron Firestein and Yoshifumi Baba and Saori Toyoda and Lei. Chen and Dr. Aparajita Hazra and Edward L. Giovannucci and Charles S. Fuchs and Shuji Ogino},
  booktitle={Modern Pathology},
  year={2009}
}
The class III histone deacetylase SIRT1 (sir2) is important in epigenetic gene silencing. Inhibition of SIRT1 reactivates silenced genes, suggesting a possible therapeutic approach of targeted reversal of aberrantly silenced genes. In addition, SIRT1 may be involved in the well-known link between obesity, cellular energy balance and cancer. However, a comprehensive study of SIRT1 using human cancer tissue with clinical outcome data is currently lacking, and its prognostic significance is… CONTINUE READING
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