SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

  title={SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive},
  author={Sergiy Libert and Kelli B Pointer and Eric L. Bell and Abhirup Das and Dena E. Cohen and John M. Asara and Karen Kapur and Sven Bergmann and Martin Preisig and Takeshi Otowa and Kenneth S. Kendler and Xiangning Chen and John M Hettema and Edwin J. C. G. van den Oord and Justin P. Rubio and Leonard P. Guarente},
SIRT1 is a NAD(+)-dependent deacetylase that governs a number of genetic programs to cope with changes in the nutritional status of cells and organisms. Behavioral responses to food abundance are important for the survival of higher animals. Here we used mice with increased or decreased brain SIRT1 to show that this sirtuin regulates anxiety and exploratory drive by activating transcription of the gene encoding the monoamine oxidase A (MAO-A) to reduce serotonin levels in the brain. Indeed… CONTINUE READING
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