SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

@article{Peck2010SIRTII,
  title={SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.},
  author={Barrie Peck and Chun-Yuan Chen and K. Ho and Paolo Di Fruscia and Stephen S. Myatt and Raul Charles Coombes and Matthew J Fuchter and C. Hsiao and Eric W-F Lam},
  journal={Molecular cancer therapeutics},
  year={2010},
  volume={9 4},
  pages={844-55}
}
SIRT proteins play an important role in the survival and drug resistance of tumor cells, especially during chemotherapy. In this study, we investigated the potency, specificity, and cellular targets of three SIRT inhibitors, Sirtinol, Salermide, and EX527. Cell proliferative and cell cycle analyses showed that Sirtinol and Salermide, but not EX527, were effective in inducing cell death at concentrations of 50 micromol/L or over in MCF-7 cells. Instead, EX527 caused cell cycle arrest at G(1) at… CONTINUE READING
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