SIRT 4 Prevents Hypoxia-Induced Apoptosis in H 9 c 2 Cardiomyoblast Cells

  • Ban Liua, Wenliang Chea, +2 authors Kai Tanga Jingying Zhanga Jing Wena Yawei Xua
  • Published 2013
Aims: Apoptosis plays a critical role in cardiomyocyte loss during ischaemic heart injury. A detailed understanding of the mechanism involved has a substantial impact on the optimization and development of treatment strategies. Here, we report that the expression of SIRT4, a mitochondrial sirtuin, is markedly down-regulated in hypoxia-induced apoptosis of… CONTINUE READING