SIRT 1 Promotes Proliferation and Prevents Senescence Through Targeting LKB 1 in Primary Porcine Aortic Endothelial Cells

@inproceedings{Zu2010SIRT1P,
  title={SIRT 1 Promotes Proliferation and Prevents Senescence Through Targeting LKB 1 in Primary Porcine Aortic Endothelial Cells},
  author={Yi Zu and Ling gang Liu and Mary Y K Lee and Cheng Xu and Yan Liang and Ricky Y. Man and Paul Michel Vanhoutte and Yu Wang},
  year={2010}
}
Rationale: Endothelial senescence causes endothelial dysfunction, promotes atherogenesis and contributes to age-related vascular disorders. SIRT1 is a conserved NAD -dependent deacetylase possessing beneficial effects against aging-related diseases, despite that the detailed functional mechanisms are largely uncharacterized. Objective: The present study is designed to evaluate the protective effects of SIRT1 on endothelial senescence and to elucidate the underlying mechanisms. Methods and… CONTINUE READING