SIRPα controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox).

Abstract

The phagocyte NADPH oxidase mediates oxidative microbial killing in granulocytes and macrophages. However, because the reactive oxygen species produced by the NADPH oxidase can also be toxic to the host, it is essential to control its activity. Little is known about the endogenous mechanism(s) that limits NADPH oxidase activity. Here, we demonstrate that… (More)
DOI: 10.1016/j.celrep.2012.08.027

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Cite this paper

@article{Beek2012SIRPCT, title={SIRPα controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox).}, author={Ellen M. van Beek and Juli{\'a}n Alvarez Z{\'a}rate and Robin van Bruggen and Karin Schornagel and Anton T. J. Tool and Takashi Matozaki and Georg Kraal and Dirk Roos and Timo K van den Berg}, journal={Cell reports}, year={2012}, volume={2 4}, pages={748-55} }