SIRAC: Supervised Identification of Regions of Aberration in aCGH datasets

@article{Lai2006SIRACSI,
  title={SIRAC: Supervised Identification of Regions of Aberration in aCGH datasets},
  author={Carmen Lai and Hugo M. Horlings and Marc J. van de Vijver and Eric H. van Beers and Petra M. Nederlof and Lodewyk F. A. Wessels and Marcel J. T. Reinders},
  journal={BMC Bioinformatics},
  year={2006},
  volume={8},
  pages={422 - 422}
}
Array comparative genome hybridization (aCGH) provides information about genomic aberrations. Alterations in the DNA copy number may cause the cell to malfunction, leading to cancer. Therefore, the identification of DNA amplifications or deletions across tumors may reveal key genes involved in cancer and improve our understanding of the underlying biological processes associated with the disease. We propose a supervised algorithm for the analysis of aCGH data and the identification of regions… CONTINUE READING
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