SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.

  title={SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.},
  author={Min Wu and Liang-Guo Xu and Zhonghe Zhai and Hong-Bing Shu},
  journal={The Journal of biological chemistry},
  volume={278 29},
The transcription factor NF-kappaB plays important roles in inflammation and cell survival. In this study, we identified SINK, an NF-kappaB-inducible protein. Overexpression of SINK inhibited NF-kappaB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but did not inhibit NF-kappaB translocation to the nucleus and binding to DNA. Co-immunoprecipitation and in vitro kinase assays indicated that SINK specifically interacted with the NF… CONTINUE READING
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