SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors

@inproceedings{Mojica2015SINCAT,
  title={SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors},
  author={Sergio A. Mojica and Kelley M. Hovis and Matthew B. Frieman and Bao Quoc Tran and Ru-Ching Hsia and Jacques Ravel and Clifton R Jenkins-Houk and Katherine L. Wilson and Patrik M. Bavoil},
  booktitle={Molecular biology of the cell},
  year={2015}
}
SINC, a new type III secreted protein of the avian and human pathogen Chlamydia psittaci, uniquely targets the nuclear envelope of C. psittaci-infected cells and uninfected neighboring cells. Digitonin-permeabilization studies of SINC-GFP-transfected HeLa cells indicate that SINC targets the inner nuclear membrane. SINC localization at the nuclear envelope was blocked by importazole, confirming SINC import into the nucleus. Candidate partners were identified by proximity to biotin ligase-fused… CONTINUE READING
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