SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease.

@article{Shirk2005SIMPLEIW,
  title={SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease.},
  author={Andrew J Shirk and S. K. Anderson and Sayed H. Hashemi and Phillip F. Chance and Craig L. Bennett},
  journal={Journal of neuroscience research},
  year={2005},
  volume={82 1},
  pages={43-50}
}
Mutation of the SIMPLE gene (small integral membrane protein of the lysosome/late endosome) is the molecular basis of Charcot-Marie-Tooth disease type 1C (CMT1C), a demyelinating peripheral neuropathy. Although the precise function of SIMPLE is unknown, prior reports suggest it localizes to the lysosome/late endosome. Furthermore, murine Simple interacts with Nedd4 (neural precursor cell expressed, developmentally downregulated 4), an E3 ubiquitin ligase that is important for regulating… CONTINUE READING
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