SILAC-based quantitative proteomic analysis of secretome between activated and reverted hepatic stellate cells.

@article{Zhang2014SILACbasedQP,
  title={SILAC-based quantitative proteomic analysis of secretome between activated and reverted hepatic stellate cells.},
  author={Hongyu Zhang and Peng Wu and Fangyan Chen and Yunwei Hao and Yuanxiang Lao and Liangliang Ren and Longqin Sun and Wei Sun and Handong Wei and Daniel Wai-Tin Chan and Ying Jiang and Fuchu He},
  journal={Proteomics},
  year={2014},
  volume={14 17-18},
  pages={1977-86}
}
Activated hepatic stellate cell (HSC) is the main myofibroblast cell in the liver fibrosis (LF). An important characteristic of the recovery of LF is not only the apoptosis of activated HSCs but also reversal of myofibroblast-like phenotype to a quiescent-like phenotype. Understanding the changes of secreted proteins in the reversion of activated HSCs may… CONTINUE READING