SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia.

  title={SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia.},
  author={J. W. Janssen and W. D. Ludwig and Wolfram Sterry and Claus Rainer Bartram},
  volume={7 8},
The TAL1 gene on chromosome 1 encodes a hematopoietic transcription factor. Disruption of TAL1 via chromosomal translocation or a site-specific deletion has been reported in up to 30% of T-cell acute lymphoblastic leukemias (T-ALL). Here we used a polymerase chain reaction (PCR) assay to identify the 90 kb SIL-TAL1 deletion in a group of 19 cutaneous T-cell lymphomas and a series of 142 T-ALL patients (76 children, 66 adults). While none of the T-cell lymphoma exhibited a SIL-TAL1 recombination… CONTINUE READING


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Proceedings of the National Academy of Sciences of the United States of America • 2018

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