SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

@article{Berdeaux2007SIK1IA,
  title={SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes},
  author={Rebecca Berdeaux and Naomi Goebel and Laura A. Banaszynski and Hiroshi Takemori and Thomas J. Wandless and Gloria Diane Shelton and Marc R. Montminy},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={597-603}
}
During physical exercise, increases in motor neuron activity stimulate the expression of muscle-specific genes through the myocyte enhancer factor 2 (MEF2) family of transcription factors. Elevations in intracellular calcium increase MEF2 activity via the phosphorylation-dependent inactivation of class II histone deacetylases (HDACs). In studies to determine the role of the cAMP responsive element binding protein (CREB) in skeletal muscle, we found that mice expressing a dominant-negative CREB… CONTINUE READING
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