SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells

@inproceedings{Li2015SIGIRRPI,
  title={SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells},
  author={Dan Li and Xin Zhang and Baiyi Chen},
  booktitle={BMC Immunology},
  year={2015}
}
The innate immune response of urinary tract is critically important in the defense to microbial attack. Toll-like receptor 4 (TLR4) controls initial mucosal response to uropathogenic Escherichia coli (UPEC). However, excessive and dysfunctional TLR signaling may result in severe inflammation and inappropriate tissue damage. Previous studies have demonstrated that single immunoglobulin IL-1R-related receptor/Toll IL-1 receptor 8 (SIGIRR/TIR8) is a member of the toll-interleukin-1 receptor (TIR… CONTINUE READING
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