SIADH Associated With Ciprofloxacin

@article{Babar2013SIADHAW,
  title={SIADH Associated With Ciprofloxacin},
  author={Sultan M. Babar},
  journal={Annals of Pharmacotherapy},
  year={2013},
  volume={47},
  pages={1359 - 1363}
}
Objective: To report a case of ciprofloxacin-induced syndrome of inappropriate antidiuretic hormone (SIADH). Case Summary: A 68-year-old Caucasian woman presented on 2 separate occasions with generalized weakness. Both times, she was started on ciprofloxacin for a urinary tract infection. Prior to the first episode, she had also been on Augmentin for several days. On both occasions, her ciprofloxacin was discontinued on admission, and her sodium levels rose. On the first occasion, she was given… 
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References

SHOWING 1-10 OF 15 REFERENCES
SIADH consecutive to ciprofloxacin intake.
The syndrome of inappropriate antidiuretic hormone secretion.
  • P. Baylis
  • Medicine, Biology
    The international journal of biochemistry & cell biology
  • 2003
Hyponatremia treatment guidelines 2007: expert panel recommendations.
  • S. A. Chubb
  • Medicine
    The Clinical biochemist. Reviews
  • 2009
Plasma sodium is one of the most commonly measured analytes in laboratory medicine and hyponatraemia is frequently observed, occurring in 15–30% of hospital patients. Severe hyponatraemia is…
Hyponatremia and hypernatremia in the elderly.
TLDR
Clinicians should have a clear appreciation of the roles that iatrogenic interventions and lapses in nutrition and nursing care frequently play in upsetting the homeostatic balance in elderly patients, particularly those who are in longterm institutional and inpatient settings.
Adverse drug reactions: implications for the development of fluoroquinolones.
  • P. Ball
  • Biology, Chemistry
    The Journal of antimicrobial chemotherapy
  • 2003
TLDR
Quinolone antibacterials, originally derived from anti-malarial compounds, have been developed through side-chain and nuclear manipulation, notably by piperazine and other mono- or bi-cyclic substitutions at the 7 position and fluorination at various sites (giving increased anti-Gram-positive activity).
Cerebrospinal fluid transport and disposition of the quinolones ciprofloxacin and pefloxacin in rats.
TLDR
The difference in CSF exposure of both quinolones and the presence of active metabolites of N-methylated quinlones in the CSF may be of clinical relevance in the treatment of CNS infections, but differences in antimicrobial activity have to be taken into account as well.
Distribution, blood transport, and degradation of antidiuretic hormone in man.
TLDR
It is concluded that in man antidiuretic hormone circulates as a free (non-protein bound) peptide, diffuses readily into the extracellular fluid space, and is metabolized within minutes.
A method for estimating the probability of adverse drug reactions
TLDR
It was shown that the ADR probability scale has consensual, content, and concurrent validity and may be applicable to postmarketing drug surveillance.
Dendritic secretion of peptides from hypothalamic magnocellular neurosecretory neurones: a local dynamic control system and its functions
TLDR
An overall picture emerges of magnocellular dendrites as active secretory and synthetic components of the neurosecretory neurones.
Syndrome of inappropriate antidiuretic hormone associated with moxifloxacin.
  • Felix K. YamS. A. Eraly
  • Medicine
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2012
TLDR
A 66-year-old Caucasian woman with stage II chronic obstructive pulmonary disease arrived at the emergency department from an outpatient clinic complaining of worsening shortness of breath, headache, body aches, and dizziness and developed severe hyponatremia after receiving moxifloxacin for five days for treatment of COPD exacerbation.
...
...